Abstract Hematopoietic stem cells (HSCs) possess the potential for self-renew and the capacity, throughout life, to differentiate into all blood cell lineages.Yet, the mechanistic basis for HSC development remains largely unknown.In this study, we characterized a zebrafish smu471 mutant with hematopoietic stem/progenitor cell (HSPC) defects and fou

BackgroundIn China, over 5 million people have been identified and registered by the public security institutions for using illicit drugs.The aim of this study is to compare the influence of different types of illicit drugs on Patient Lifts the self-reported mental health of Chinese people.In particular, we want to assess the damage of Heroin, Meth

Summary: Galactose (Gal)-deficient IgA1 (Gd-IgA1) is involved in IgA nephropathy (IgAN) pathogenesis.To reflect Pillow Protector racial differences in clinical characteristics, we assessed disease- and race-specific heterogeneity in the O-glycosylation of the IgA1 hinge region (HR).We determined serum Gd-IgA1 levels in Caucasians (healthy controls

Disturbance compensation is an important criteria to evaluate the performance of a photoelectric tracking servo control system.In order to effectively compensated disturbance in high frequency, a novel sliding mode disturbance observer (NSMDOB) is proposed in this paper.The dynamic performance of the system is improved by the design of the compound

The recently developed CRISPR screen technology, based on the CRISPR/Cas9 genome editing system, enables genome-wide interrogation of gene functions in an efficient and cost-effective manner.Although many computational algorithms and web servers have been developed to design FLORASIL single-guide RNAs (sgRNAs) with high specificity and efficiency,